The Low Country region has a subtropical climate and beautiful coast and Sea Islands, which run down the southeastern coast of the United States in the Atlantic Ocean. It is known for its distinct historic culture and natural beauty and is a popular tourist destination.

One of the most distinctive features of this region is the architecture. Since the late 1700s, a style of home architecture is used which is considered to be the most efficient design for the hot subtropical climate of the area. The economy of the area was originally based on plantation agriculture, which included indigo, rice and cotton. In recent times, the economy is dominated by tourism. There are many resorts, historic and cultural sites and areas of natural beauty, including several state and nationally protected and preserved lands and wetlands. The area offers many resorts for golf, tennis and beach vacations, such as Hilton Head Island, one of the most popular resort destinations in the U.S. Other popular resorts include Fripp Island, Seabrook Island and Kiawah Island. The city of Charleston is also a popular tourist destination, with many historical sites and cultural activities.

In addition to tourism, much of the economy also includes manufacturing, transportation, logistics and other port- related industry. There are also several major shopping areas in this region. There are also several U.S. military bases in the region, including Air Force, Navy, Marines and National Guard outposts.

Beaufort County is one of the fastest growing counties in the South, mainly due to development south of the Broad River. The northern area of the county has grown steadily, due to the strong federal military presence around the city of Beaufort. The county features the Pinckney Island National Wildlife Refuge and the Ernest F. Hollings ACE Basin National Wilde Life Refuge. Large cities include Beaufort, which is also the county seat, Hilton Head Island and Bluffton.

Charleston County is the third most populated county in South Carolina and the largest by total land and water area. Charleston is the largest city and the county seat. The county has several wildlife refuges and historic sites, including forts from the United States Civil War. As the county borders the Atlantic Ocean, it contains many beach resorts and parks, marinas and fishing piers.

Dorchester County's largest city is North Charleston, the third largest city in the state of South Carolina. St. George is the county seat. The county was named for Dorchester, Massachusetts, as Congregationalists from that town moved south to establish a new settlement. The county is home to Francis Beidler Forest in the Four Holes Swamp, which contains the largest remaining stand of old-growth cypress and tupelo gum trees in the world. Berkeley County is adjacent to Dorchester County, and contains part of the Francis Marion National Forest and Lake Marion. Other attractions include Cypress Gardens, Mepkin Abbey and Berkeley County Museum and Heritage Center. The largest city is Charleston, a portion of which is in Berkeley County. The county also includes a portion of North Charleston, and Goose Creek is an additional large city.